#01 Nancy King — Gene Editing, Enhancement, and the Purview of Biotechnologies

 

Shownotes

• About Nancy King

• Nancy’s Article on Gene Editing: Human Gene-Editing Research: Is the Future Here Yet?

• The evolution of genome editing
• Broad Institute’s review of CRISPR
• The Precautionary Principle
• Chesterton’s Fence
• Base editing
• David Liu’s 2019 prime editing paper
• Prime editing review
• Discovery of the double helix by Watson and Crick
• Rosalind Franklin
• Gene therapy
• The very short list of FDA-approved cellular and gene therapies
• Review article on gene therapy
• Dor Yeshorim: Jewish assortative mating to prevent Tay Sachs
• Tiger Woods’ lasik surgery enhancement
• “Circumvention tourism”
• Nick Bostrom’s “Vulnerable World Hypothesis”
• “Slow-motion disaster”
• Brian Earp on oxcytocin for moral enhancement
• ‘Oxytocin promotes coordinated out-group attack during intergroup conflict in humans’
• ‘Oxytocin promotes human ethnocentrism’
• David Pearce on the abolition of suffering
• “David Pearce—The Hedonistic Imperative: How Good is Good?”

 

Topics Discussed and Timestamps

Coming soon.

Note: I used the language of factor analysis (FA) and principal components analysis (PCA) rather loosely when talking about fluid intelligence; the two techniques are similar but not identical.

• Does PCA = FA?
• Factor analysis and PCA
• Eigenvectors and computing principal components